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Template-controlled synthesis of chiral cyclohexylhemicucurbit[8]uril

2015

Enantiomerically pure cyclohexylhemicucurbit[8]uril (cycHC[8]), possessing a barrel-shaped cavity, has been prepared in high yield on a gram scale from either (R,R,N,N')-cyclohex-1,2-diylurea and formaldehyde or cycHC[6]. In either case, a dynamic covalent library is first generated from which the desired cycHC can be amplified using a suitable anion template.

Metals and AlloysFormaldehydeGeneral Chemistryhost-guest sytemscycHC synthesisCombinatorial chemistryCatalysisSurfaces Coatings and FilmsElectronic Optical and Magnetic Materialschemistry.chemical_compoundchemistryCovalent bondYield (chemistry)Materials ChemistryCeramics and Compositesta116Chemical Communications
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